Our research laboratory (located in Iceland and Baltimore) focuses on understanding how disruption of epigenetic modifications leads to disease states and exploring whether manipulation of epigenetic modifications can rescue some of these disease states.
We do this by:
1) Study of the Mendelian disorders of the Epigenetic machinery;
2) Detailed study of samples from patients and mouse models of model Mendelian disorders of the epigenetic machinery (Kabuki syndrome, Rubinstein-Taybi syndrome, Wiedemann-Steiner syndrome and Pilarowski-Bjornsson syndrome);
3) Study of the entire set of human epigenetic components (295 components that play a role in maintaining epigenetic modifications);
4) We also study novel therapeutic approaches for other neurological diseases.
The Björnsson laboratory