Research publications (w/graphical abstract)     |     Research publications (w/o graphical abstract)     |     Reviews and others

Highly efficient polarizing agents for MAS‐DNP of proton‐dense molecular solids
Harrabi R, Halbritter T, Aussenac F, Dakhlaoui O, van Tol J, Damodaran K, Lee D, Paul S, Hediger S, Mentink-Vigier F, Sigurdsson ST, De Paëpe G
Angew. Chem. Int. Ed. 2022, , in press.
DOI: 10.1002/anie.202114103.
A carbazole-derived nitroxide that is an analogue of cytidine: A rigid spin label for DNA and RNA
Segler A-LJ; Sigurdsson ST
J. Org. Chem. 2021, 86, 11647–59.
DOI: 10.1021/acs.joc.1c01176. [PDF]
The distance between g-tensors of nitroxide biradicals governs MAS-DNP performance: The case of the bTurea family
Mentink-Vigier F, Dubroca T, Van Tol J, Sigurdsson ST
J. Magn. Reson. 2021, 329, 107026.
DOI: 10.1016/j.jmr.2021.107026. [PDF]
Water-soluble BDPA radicals with improved persistence
Mandal S, Sigurdsson ST
Chem. Commun. 2020, 56, 13121-24.
DOI: 10.1039/D0CC04920D. [PDF]
Compaction of RNA duplexes in the cell
Collauto A, von Bülow S, Gophane DB, Saha S, Stelzl L, Hummer G, Sigurdsson ST, Prisner TF
Angew. Chemie Int. Ed. 2020, 59, 23025-9.
DOI: 10.1002/anie.202009800. [PDF]
Nitroxide-derived N-oxide phenazines for noncovalent spin-labeling of DNA
Juliusson HY, Sigurdsson ST
ChemBioChem 2020, 21, 2635-42.
DOI: 10.1002/cbic.202000128. [PDF]
On the stability of BDPA radicals
Mandal S, Sigurdsson ST
Chem. Eur. J. 2020, 26, 7486-91.
DOI: 10.1002/chem.202001084. [PDF]
Characterization of frequency-chirped dynamic nuclear polarization in rotating solids
Judge PT, Sesti EL, Alaniva N, Saliba EP, Price LE, Gao C, Halbritter T, Sigurdsson ST, Kyei GB, Barnes AB
J. Magn. Res. 2020, 313, 106702.
DOI: 10.1016/j.jmr.2020.106702. [PDF]
Dynamic nuclear polarization with electron decoupling in intact human cells and cell lysates
Judge PT, Sesti EL, Price LE, Albert BA, Alaniva N, Saliba EP, Halbritter T, Sigurdsson ST, Kyei GB, Barnes AB
J. Phys. Chem. B. 2020, 124, 2323-30.
DOI: 10.1021/acs.jpcb.9b10494. [PDF]
Reduction resistant and rigid spin labels for DNA and RNA
Juliusson HY, Sigurdsson ST
J. Org. Chem. 2020, 85, 4036-46.
DOI: 10.1021/acs.joc.9b02988. [PDF]
Noncovalent spin‐labeling of DNA and RNA triplexes
Richert C, Kamble N, Wolfrum M, Halbritter T, Sigurdsson ST
Chem. Biodiversity 2020, 17, e1900676.
DOI: 10.1002/cbdv.201900676. [PDF]
High-resolution EPR distance measurements on RNA and DNA with the non-covalent Ǵ spin label
Heinz M, Erlenbach N, Stelzl L, Thierolf G, Kamble NR; Sigurdsson ST, Prisner T, Hummer G
Nucleic Acids Res. 2020, 48, 924-33.
DOI: 10.1093/nar/gkz1096. [PDF]
Paramagnetic-iterative relaxation matrix approach – extracting PRE-restraints from NOESY spectra for 3D structure elucidation of biomolecules
Cetiner EC, Jonker HRA, Helmling C, Gophane DB, Grünewald C, Sigurdsson ST, Schwalbe H
J. Biomol. NMR. 2019, 73, 699-712.
DOI: 10.1007/s10858-019-00282-0. [PDF]
Frequency-chirped dynamic nuclear polarization with magic angle spinning using a frequency-agile gyrotron
Gao C, Alaniva N, Saliba EP, Sesti EL, Judge PT, Scott FJ, Halbritter T, Sigurdsson ST, Barnes AB
J. Magn. Res. 2019, 308, 106586.
DOI: 10.1016/j.jmr.2019.106586. [PDF]
Sensitivity analysis of magic angle spinning dynamic nuclear polarization below 6 K
Judge PT, Sesti EL, Saliba EP, Alaniva N, Halbritter T, Sigurdsson ST, Barnes AB
J. Magn. Res. 2019, 305, 51-7.
DOI: 10.1016/j.jmr.2019.05.011. [PDF]
Benzoyl‐protected hydroxylamines for improved chemical synthesis of oligonucleotides containing nitroxide spin labels
Juliusson HY, Segler A-LJ, Sigurdsson ST
Eur. J. Org Chem 2019, 23, 3799-805.
DOI: 10.1002/ejoc.201900553. [PDF]
Structure guided fluorescence labeling reveals a two-step binding mechanism of neomycin to its RNA aptamer
Gustmann H, Segler A-LJ, Gophane DB, Reuss AJ, Grünewald C, Braun M, Sigurdsson ST, Wachtveitl J
Nucleic Acids Res. 2019, 47, 15-28.
DOI: 10.1093/nar/gky1110. [PDF]
Influence of Mg2+ on the conformational flexibility of a tetracycline aptamer
Hetzke T, Vogel M, Gophane DB, Weigand JE, Suess B, Sigurdsson ST, Prisner TF
RNA 2019, 25, 158-167.
DOI: 10.1261/rna.068684.118. [PDF]
Noncovalent spin-labeling of RNA: The aptamer approach
Saha S, Hetzke T, Prisner TF, Sigurdsson ST
Chem. Commun. 2018, 54, 11749-52.
DOI: 10.1039/c8cc05597a. [PDF]
Orientation selective 2D-SIFTER experiments at X-band frequencies
Bowen A, Erlenbach N, van Os P, Stelzl L, Sigurdsson ST, Prisner TF
Appl. Magn. Reson. 2018, 49, 1355-68.
DOI: 10.1007/s00723-018-1057-3. [PDF]
Computationally-assisted design of polarizing agents for dynamic nuclear polarization enhanced NMR: the AsymPol family
Mentink-Vigier F, Marin-Montesinos I, Jagtap AP, Halbritter T, van Tol J, Hediger S, Lee D, Sigurdsson ST, De Paëpe G
J. Am. Chem. Soc. 2018, 140, 11013-9.
DOI: 10.1021/jacs.8b04911. [PDF]
Dynamic Nuclear Polarization NMR in human cells using fluorescent polarizing agents
Sesti EL, Albert BJ, Gao C, Saliba EP, Alaniva N, Scott FJ, Golota NC, Pahng SH, Sigurdsson ST, Barnes AB
Biochemistry 2018, 57, 4741-6.
DOI: 10.1021/acs.biochem.8b00257. [PDF]
Dynamics of nucleic acids at room temperature revealed by pulsed EPR
Gränz M, Erlenbach N, Spindler P, Gophane DB, Stelzl LS, Sigurdsson ST, Prisner TF
Angew. Chem. Int. Ed. 2018, 57, 10540-43.
DOI: 10.1002/anie.201803682. [PDF]
Efficiency of water-soluble nitroxide biradicals for dynamic nuclear polarization in rotating solids at 9.4 T: bcTol-M and cyolyl-TOTAPOL as new polarizing agents
Geiger M-A, Jagtap AP, Kaushik M, Sun H, Stöppler D, Sigurdsson ST, Corzilius B, Oschkinat H
Chem. Eur. J. 2018, 24, 13485-94.
DOI: 10.1002/chem.201801251. [PDF]
Purine-derived nitroxides for noncovalent spin-labeling of abasic sites in duplex nucleic acids
Kamble NR, Sigurdsson ST
Chem. Eur. J. 2018, 24, 4157-64.
DOI: 0.1002/chem.201705410. [PDF]
Frequency-agile gyrotron for electron decoupling and pulsed dynamic nuclear polarization
Scott FJ, Saliba EP, Albert BJ, Alaniva N, Sesti EL, Gao C, Golota NC, Choi EJ, Jagtap AP, Whitman JJ, Eckardt M, Harneit W, Corzilius B, Sigurdsson ST, Barnes AB
J. Magn. Reson. 2018, 289, 45-54.
DOI: 10.1016/j.jmr.2018.02.010. [PDF]
A semi-rigid isoindoline-derived nitroxide spin label for RNA
Gophane DB, Endeward B, Prisner TF, Sigurdsson ST
Org. Biomol. Chem. 2018, 16, 816-24.
DOI: 10.1039/c7ob02870a. [PDF]
Determination of helix orientations in a highly flexible DNA by multi-frequency EPR spectroscopy
Grytz CM, Kazemi S, Marko A, Cekan P, Güntert P, Sigurdsson ST, Prisner TF
Phys. Chem. Chem. Phys. 2017, 19, 29801-11.
DOI: 10.1039/C7CP04997H. [PDF]
Spin the light off: Rapid internal conversion into a dark doublet state quenches the fluorescence of an RNA spin-label
Gustmann H,, Lefrancois D, Reuss AJ, Gophane DB, Braun M, Dreuw A, Sigurdsson ST, Wachtveitl J
Phys. Chem. Chem. Phys. 2017, 19, 26255-64.
DOI: 10.1039/C7CP03975A. [PDF]
Characterization of V-Mo-W mixed oxide catalyst surface species by 51V solid-state dynamic nuclear polarization NMR
Thankamony A, Knoche S, Bothe S, Drochner A, Jagtap AP, Sigurdsson ST, Vogel H, Etzold B, Gutmann T, Buntkowsky G
J. Phys. Chem. C. 2017, 121, 20857–64.
DOI: 10.1021/acs.jpcc.7b06761. [PDF]
Impact of spin label rigidity on extent and accuracy of distance information from PRE data
Schnorr K, Gophane DB, Helmling C, Cetiner E, Pasemann K, Fürtig B, Wacker A, Qureshi NS, Gränz M, Barthelmes D, Jonker HRA, Stirnal E, Sigurdsson ST, Schwalbe H
J. Biomol. NMR 2017, 68, 53-63.
DOI: 10.1007/s10858-017-0114-9. [PDF]
Dynamic nuclear polarization provides new insights into chromophore structure in phytochrome photoreceptors
Stöppler D, Song C, van Rossum B-J, Geiger M-A, Lang C, Mroginski M-A, Jagtap AP, Sigurdsson ST, Matysik J, Hughes J, Oschkinat H
Angew. Chem. Int. Ed. 2016, 55, 16017-20.
DOI: 10.1002/anie.201608119. [PDF]
Noncovalent and site-directed spin labeling of duplex RNA
Kamble NR, Gränz M, Prisner TF, Sigurdsson ST
Chem. Comm. 2016, 52, 14442-5.
DOI: 10.1039/c6cc08387k. [PDF]
Quantitative UPLC–MS/MS assay of urinary 2,8-dihydroxyadenine for diagnosis and management of adenine phosphoribosyltransferase deficiency
Thorsteinsdottir M, Thorsteinsdottir UA, Eiriksson FF, Runolfsdottir HL, Agustsdottir IMSch, Oddsdottir S, Sigurdsson BB, Hardarson HK, Kamble NR, Sigurdsson ST, Edvardsson VO, Palsson R
J. Chromatogr. B 2016, 1036-, 170-7.
DOI: 10.1016/j.jchromb.2016.09.018. [PDF]
Flexibilities of isoindoline-derived spin labels for nucleic acids by orientation selective PELDOR
Erlenbach N, Endeward B, Gophane DB, Sigurdsson ST, Prisner TF
Phys. Chem. Chem. Phys. 2016, 18, 16196-201.
DOI: 10.1039/C6CP02475K. [PDF]
bcTol: A highly water-soluble biradical for efficient dynamic nuclear polarization of biomolecules
Jagtap AP, Geiger M-A, Stöppler D, Orwick-Rydmark M, Oschkinat H, Sigurdsson ST
Chem. Comm. 2016, 52, 7020-3.
DOI: 10.1039/C6CC01813K. [PDF]
Flexibility and Conformation of the Cocaine Aptamer Studied by PELDOR
Grytz CM, Marko A, Cekan P, Sigurdsson ST, Prisner TF
Phys. Chem. Chem. Phys. 2016, 18, 2993-3002.
DOI: 10.1039/c5cp06158j. [PDF]
Pulsed EPR dipolar spectroscopy at Q- and G-band on a trityl biradical
Akhmetzyanov D, Schöps P, Marko A, Kunjir NC, Sigurdsson ST, Prisner TF
Phys. Chem. Chem. Phys. 2015, 17, 24446-51.
DOI: 10.1039/C5CP03671B. [PDF]
Site-directed spin labeling of 2´-amino groups in RNA with isoindoline nitroxides that are resistant to reduction
Saha S, Jagtap AP, Sigurdsson ST
Chem. Comm. 2015, 51, 13142-5.
DOI: 10.1039/C5CC05014F. [PDF]
Distance measurements between manganese(II) and nitroxide spin-labels by DEER determine a binding site of Mn2+ in the HP92 loop of ribosomal RNA
Kaminker I, Bye M, Mendelman N, Gislason K, Sigurdsson ST, Goldfarb D
Phys. Chem. Chem. Phys 2015, 17, 15098-102.
DOI: 10.1039/C5CP01624J. [PDF]
TEMPO-derived spin labels linked to the nucleobases adenine and cytosine for probing local structural perturbations in DNA by EPR spectroscopy
Gophane DB, Sigurdsson ST
Beilstein J. Org. Chem. 2015, 11, 219-227.
DOI: 10.3762/bjoc.11.24. [PDF]
Natural abundance N15 NMR by dynamic nuclear polarization: Fast analysis of binding sites of a novel amine-carboxyl-linked immobilized dirhodium catalyst
Gutmann T, Liu J, Rothermel N, Xu Y, Jaumann E, Breitzke H, Sigurdsson ST, Buntkowsky G
Chem. Eur J. 2015, 21, 3798-805.
DOI: 10.1002/chem.201405043. [PDF]
Sterically shielded spin labels for in-cell EPR spectroscopy: Analysis of stability in reducing environment
Jagtap AP, Krstic I, Kunjir NC, Hänsel R, Prisner TF, Sigurdsson ST
Free Radical Res. 2015, 49, 78-85.
DOI: 10.3109/10715762.2014.979409. [PDF]
TMIO-PyrImid hybrids are profluorescent, site-directed spin labels for nucleic acids
Chalmers BA, Saha S, Nguyen T, McMurtrie J, Sigurdsson ST, Bottle SE, Masters K-S
Org. Lett. 2014, 16, 5528-31.
DOI: 10.1021/ol502003a. [PDF]
Conformationally restricted isoindoline-derived spin labels in duplex DNA: Distances and rotational flexibility by PELDOR
Gophane DB, Endeward B, Prisner TF, Sigurdsson ST
Chem. Eur. J. 2014, 20, 15913–9.
DOI: 10.1002/chem.201403726. [PDF]
Nitroxide-labeled pyrimidines for noncovalent spin-labeling of abasic sites in DNA and RNA duplexes
Shelke SA, Sandholt GB, Sigurdsson ST
Org. Biomol. Chem. 2014, 12, 7366-74.
DOI: 10.1039/C4OB01095G. [PDF]
Measurements of short distances between trityl spin labels with CW EPR, DQC and PELDOR
Kunjir N, Reginsson GW, Schiemann O, Sigurdsson ST
Phys. Chem. Chem. Phys. 2013, 15, 19673-85.
DOI: 10.1039/c3cp52789a. [PDF]
A single-stranded junction modulates nanosecond motional ordering of the substrate recognition duplex of a group I ribozyme
Nguyen P, Shi X, Sigurdsson ST, Herschlag D, Qin PZ
ChemBioChem 2013, 14, 1720-3.
DOI: 10.1002/cbic.201300376. [PDF]
Orientation selection in distance measurements between nitroxide spin labels at 94 GHz EPR with variable dual frequency irradiation
Tkach I, Pornsuwan S, Höbartner C, Wachowius F, Sigurdsson ST, Baranova TY, Diederichsen U, Sicoli G, Bennati M
PhysChemChemPhys 2013, 15, 3433-7.
DOI: 10.1039/C3CP44415E. [PDF]
Rigid 5’-6-locked phenanthroline-derived nucleosides chelated to ruthenium and europium ions
Gislason K, Sigurdsson ST
Bioorg. Med. Chem. Lett. 2013, 23, 264-7.
DOI: 10.1016/j.bmcl.2012.10.104. [PDF]
Hydrogen-bonding controlled rigidity of an isoindoline-derived nitroxide spin label for nucleic acids
Gophane DB, Sigurdsson ST
Chem. Comm. 2013, 49, 999-1001.
DOI: 10.1039/c2cc36389e. [PDF]
Protein-induced changes in DNA structure and dynamics observed with noncovalent site-directed spin labeling and PELDOR
Reginsson GW, Shelke SA, Rouillon C, White M, Sigurdsson ST, Schiemann O
Nucleic Acids Res. 2013, 41, e11.
DOI: 10.1093/nar/gks817. [PDF]
Syntheses and photophysical properties of 5´-6 locked fluorescent nucleosides
Gíslason K, Gophane DB, Sigurdsson ST
Org. Biomol. Chem. 2013, 11, 149-57.
DOI: 10.1039/c2ob26536b. [PDF]
Synthesis and characterization of RNA containing a rigid and nonperturbing cytidine-derived spin label
Höbartner C, Sicoli G, Wachowius F, Gophane DB, Sigurdsson ST
J. Org. Chem. 2012, 78, 7749-54.
DOI: 10.1021/jo301227w. [PDF]
Trityl radicals: Spin labels for nanometer distance measurements
Reginsson GW, Kunjir N, Sigurdsson ST, Schiemann O
Chem. Eur. J. 2012, 18, 13580-4.
DOI: 10.1002/chem.201203014. [PDF]
Conformation and dynamics of nucleotides in bulges and symmetric internal loops in duplex DNA studied by EPR and fluorescence spectroscopies
Cekan P, Sigurdsson ST
Biochem. Biophys. Res. Comm. 2012, 420, 656-61.
DOI: 10.1016/j.bbrc.2012.03.059. [PDF]
W-Band PELDOR with 1kW Microwave Power: Molecular Geometry, Flexibility and Exchange Coupling Anisotropy
Reginsson GW, Hunter RI, Cruickshank PAS, Bolton DR, Sigurdsson ST, Smith GM, Schiemann O
J. Magn. Reson. 2012, 216, 175-82.
DOI: 10.1016/j.jmr.2012.01.019. [PDF]
A mass spectrometric study on sodium ion induced central nucleotide deletion in the gas phase
Flosadottir HD, Gislason K, Sigurdsson ST, Ingolfsson O
J. Am. Soc. Mass Spectrom. 2012, 23, 690-8.
DOI: 10.1007/s13361-011-0335-1. [PDF]
Effect of N3-modifications on the affinity of spin label ç for abasic sites in duplex DNA
Shelke SA, Sigurdsson ST
ChemBioChem 2012, 13, 684-90.
DOI: 10.1002/cbic.201100728. [PDF]
Structural changes of an abasic site in duplex DNA affect noncovalent binding of the spin label ç
Shelke SA, Sigurdsson ST
Nucleic Acids Res. 2012, 40, 3732-40.
DOI: 10.1093/nar/gkr1210. [PDF]
Conformational flexibility of DNA
Marko A, Denysenkov V, Margraf D, Cekan P, Schiemann O, Sigurdsson ST, Prisner TF
J. Am. Chem. Soc. 2011, 133, 13375-79.
DOI: 10.1021/ja201244u. [PDF]
Experimental and theoretical study of the metastable decay of negatively charged nucleosides in the gas phase
Flosadottir HD, Jonsson H, Sigurdsson ST, Ingolfsson O
Phys. Chem. Chem. Phys. 2011, 13, 15283-90.
Simulating electron spin resonance spectra of macromolecules labeled with two dipolar-coupled nitroxide spin labels from trajectories
Sezer D, Sigurdsson ST
Phys. Chem. Chem. Phys. 2011, 13, 12785-97.
Crystal structure of a DNA containing the planar, phenoxazine-derived bifunctional spectroscopic probe Ç
Edwards TE, Cekan P, Reginsson GW, Shelke SA, Ferre D´Amare A, Schiemann O, Sigurdsson ST
Nucleic Acids Res. 2011, 39, 4419-26.
DOI: 10.1093/nar/gkr015. [PDF]
Structure-function relationships of phenoxazine nucleosides for mismatch identification in duplex DNA by fluorescence spectroscopy
Gardarson H, Kale A, Sigurdsson ST
ChemBioChem 2011, 12, 567-75.
Nitroxides and nucleic acids: Chemistry and electron paramagnetic resonance (EPR) spectroscopy
Sigurdsson ST
Pure. Appl. Chem. 2011, 83, 677-86.
Non-covalent and site-directed spin-labeling of nucleic acids
Shelke SA, Sigurdsson ST
Angew. Chem. Int. Ed. 2010, 49, 7984-6.
DOI: 10.1002/anie.201002637. [PDF]
Synthesis of a 5´-6 locked 1,10-phenanthroline-containing nucleoside and its incorporation into DNA
Gislason K, Sigurdsson ST
Eur. J. Org. Chem. 2010, , 4713-8.
Large flanking sequence effects in single nucleotide mismatch detection using fluorescent nucleoside Çf
Gardarsson H, Sigurdsson ST
Bioorg. Med. Chem. 2010, 18, 6121-6.
Site-directed spin-labeling of DNA using click-chemistry. Detection of abasic sites in duplex DNA by EPR spectroscopy
Jacobsen U, Shelke SA, Vogel S, Sigurdsson ST
J. Am. Chem. Soc. 2010, 132, 10424-8.
DOI: 10.1021/ja102797k. [PDF]
Analytical method to determine the orientation of rigid spin labels in DNA
Marko A, Margraf D, Cekan P, Sigurdsson ST, Schiemann O, Prisner TF
Phys. Rev. E. 2010, 81, 21911-9.
Identification of single-base mismatches in duplex DNA by EPR spectroscopy
Cekan P, Sigurdsson ST
J. Am. Chem. Soc. 2009, 131, 18054-6.
DOI: 10.1021/ja905623k. [PDF]
Ferro- and antiferromagnetic exchange coupling constants in PELDOR Spectra
Margraf D, Cekan P, Prisner TF, Sigurdsson ST, Schiemann O
Phys. Chem. Chem. Pys. 2009, 11, 6780-14.
DOI: 10.1039/B905524J. [PDF]
Folding of the cocaine aptamer studied by EPR and fluorescence spectroscopies using the bifunctional spectroscopic probe Ç
Cekan P, Jonsson EÖ, Sigurdsson ST
Nucleic Acids Res. 2009, 37, 3390-95.
Relative orientation of rigid nitroxides by PELDOR: Beyond distance measurements in nucleic acids
Schiemann O, Cekan P, Margraf D, Prisner TF, Sigurdsson ST
Angew. Chem. Int. Ed. 2009, 48, 3292-95.
DOI: 10.1002/anie.200805152. [PDF]
Structural features and dynamics of a cold-adapted alkaline phosphatase studied by EPR spectroscopy
Heidarsson PO, Sigurdsson ST, Ásgeirsson B
FEBS J. 2009, 276, 2725-35.
Conformational equilibria of bulged sites in duplex DNA studied by EPR spectroscopy
Smith AL, Cekan P, Brewood GP, Okonogi TM, Alemayehu S, Hustedt EJ, Benight AS, Sigurdsson ST, Robinson BH
J. Phys. Chem. B 2009, 113, 2664-75.
Theory for spin-lattice relaxation of spin probes on weakly deformable DNA
Begg ALS, Cekan P, Rangel DP, Sigurdsson ST, Mailer C, Robinson BH
J. Phys. Chem. B 2008, 112, 9219-36.
tert-Butyldimethylsilyl O-protected chitosan and chitooligosaccharides: Useful precursors for N-modifications in common organic solvents
Rúnarsson ÖV, Malainer C, Holappa J, Sigurdsson ST, Masson M
Carbohyd. Res. 2008, 343, 2576-82.
Rigid spin-labeled nucleoside Ç: A non-perturbing probe of nucleic acid conformation
Cekan P, Smith AL, Barhate N, Robinson BH, Sigurdsson ST
Nucleic Acids Res. 2008, 36, 5946-54.
Single base interrogation by a fluorescent nucleoside: Each of the four bases of DNA identified by fluorescence spectroscopy
Cekan P, Sigurdsson ST
Chem. Comm. 2008, , 3393-5.
A nonafluoro-nucleoside as a sensitive 19F NMR probe of nucleic acid conformation
Barhate N, Barhate R, Cekan P, Drobny G, Sigurdsson ST
Org. Lett. 2008, 10, 2745-7.
Site-specific incorporation of nitroxide spin-labels into 2´-positions of nucleic acids
Edwards TE, Sigurdsson ST
Nature Protocols 2007, 2, 1954-62.
A nucleoside that contains a rigid nitroxide spin label: A fluorophore in disguise
Barhate N, Cekan P, Massey AP, Sigurdsson ST
Angew. Chem. Int. Ed. 2007, 46, 2655-8.
Using solid-state 31P {19F} REDOR NMR to measure distances between a trifluoromethyl group and a phosphodiester in nucleic acids
Louie EA, Chirakul P, Raghunathan V, Sigurdsson ST, Drobny GP
J. Magn. Res. 2006, 178, 11-24.
EPR spectroscopic analysis of U7 hammerhead ribozyme dynamics during metal ion-induced folding
Edwards TE, Sigurdsson ST
Biochemistry 2005, 44, 12870-8.
Monitoring tat peptide binding to TAR RNA by solid-state 31P-19F REDOR NMR
Olsen GL, Edwards TE, Deka P, Varani G, Sigurdsson ST, Drobny GP
Nucleic Acids Res. 2005, 33, 3447-54.
Use of enzymes in organic synthesis: Reduction of ketones by baker´s yeast revisited
Patterson J, Sigurdsson ST
J. Chem. Ed. 2005, 82, 1049-50.
Identification of amino acids that promote specific and rigid TAR RNA-Tat protein complex formation
Edwards TE, Robinson BH, Sigurdsson ST
Chem Biol. 2005, 12, 329-337.
Investigation of Mg2+- and temperature-dependent folding of the hairpin ribozyme by photocross-linking: Effects of photocrosslinker tether length and chemistry
Borda EJ, Sigurdsson ST
Nucleic Acids Res. 2005, 33, 1058-68.
Isolation and characterization of a thermostable RNA ligase 1 from a Thermus scotoductus bacteriophage TS2126 with good single-stranded DNA ligation properties
Blondal T, Thorisdottir A, Unnsteinsdottir U, Hjorleifsdottir S, Aevarsson A, Ernstsson S, Fridjonsson OH, Skirnisdottir S, Wheat JO, Hermannsdottir AG, Sigurdsson ST, Hreggvidsson GO, Smith AV, Kristjansson JK
Nucleic Acids Res. 2005, 33, 135-42.
A new alpha-helical extension promotes RNA binding by the dsRBD of Rnt1p RNAse III
Leulliot N, Quevillon-Cheruel S, Graille M, Van Tilbeurgh H, Leeper TC, Godin KS, Edwards TE, Sigurdsson ST, Rozenkrants N, Nagel RJ, Ares M, Varani G
EMBO J. 2004, 23, 2468-77.
Sequence context effect on the structure of nitrous acid induced DNA interstrand cross-links
Edfeldt NBF, Harwood EA, Sigurdsson ST, Hopkins PB, Reid BR
Nucleic Acids Res. 2004, 32, 2795-801.
Solution structure of a nitrous acid induced DNA interstrand cross-link
Edfeldt NBF, Harwood EA, Sigurdsson ST, Hopkins PB, Reid BR
Nucleic Acids Res. 2004, 32, 2785-94.
Chemical syntheses of inhibitory substrates of the RNA-RNA ligation reaction catalyzed by the hairpin ribozyme
Massey AP, Sigurdsson, ST
Nucleic Acids Res. 2004, 32, 2017-22.
Interactions of the antibiotics neomycin B and chlortetracycline with the hammerhead ribozyme as studied by Zn2+-dependent RNA cleavage
Borda EJ, Sigurdsson ST
Bioorg Med Chem 2004, 12, 1023-8.
Structural investigation of a high-affinity MnII binding site in the hammerhead ribozyme by EPR spectroscopy and DFT calculations. Effects of neomycin B on metal-ion binding.
Schiemann O, Fritscher J, Kisseleva N, Sigurdsson ST, Prisner TF
ChemBioChem 2003, 4, 1057-65.
Unexpected formation of 2'-deoxy-N3-(3,3,3-trifluoro-1-propenyl)uridine via a Michael-type addition to 3,3,3-trifluoropropyne
Chirakul P, Sigurdsson ST
Tet Lett. 2003, 44, 6899-901.
Determination of DNA minor groove width in distamycin-DNA complexes by solid-state NMR
Olsen GL, Louie EA, Drobny GP, Sigurdsson ST
Nucleic Acids Res. 2003, 31, 5084-9.
Zinc-dependent cleavage in the catalytic core of the hammerhead ribozyme: Evidence for a pH-dependent conformational change
Borda EJ, Markley J, Sigurdsson ST
Nucleic Acids Res. 2003, 31, 2595-600.
EPR spectroscopic analysis of TAR RNA-metal ion interactions
Edwards TE, Sigurdsson ST
Biochem Biophys Res Comm. 2003, 303, 721-5.
Stereospecific synthesis of 3'-deuterium-labelled pyrimidine nucleosides and their site-specific incorporation into DNA
Chirakul P, Sigurdsson ST
Org Lett. 2003, 5, 917-9.
Nanometer distance measurements on RNA using PELDOR
Schiemann O, Weber A, Edwards TE, Prisner TF, Sigurdsson ST
J Am Chem Soc. 2003, 125, 3434-5.
Electron paramagnetic resonance dynamic signatures of TAR RNA-small molecule complexes provide insight into RNA structure and recognition
Edwards TE, Okonogi TM, Sigurdsson ST
Biochemistry 2002, 41, 14843-7.
Transition state stabilization by a catalytic RNA
Rupert P, Massey AP, Sigurdsson ST, Ferre D'Amare A
Science 2002, 298, 1421-24.
Investigation of RNA-protein and RNA-metal ion interactions by electron paramagnetic resonance spectroscopy: The TAR-tat motif
Edwards TE, Okonogi TM, Sigurdsson ST
Chem Biol. 2002, 9, 699-706.
Identification and characterization of a divalent metal ion-dependent cleavage site in the hammerhead ribozyme
Markley J, Godde F, Sigurdsson ST
Biochemistry 2001, 40, 13849-56.
Preparation of base-deuterated 2’-deoxyadenosine nucleosides and their site-specific incorporation into DNA
Chirakul P, Litzer JR, Sigurdsson ST
Nucleotides, Nucleosides & Nucleic Acids 2001, 20, 1903-13.
Incorporation of 2'-deoxy-5-(trifluoromethyl)uridine and 5-cyano-2'-deoxyuridine into DNA
Markley J, Chirakul P, Sologub D, Sigurdsson ST
Bioorg Med Chem Lett. 2001, 11, 2453-5.
Site-specific incorporation of nitroxide spin labels into internal sites of the TAR RNA; Structure-dependent dynamics of RNA by EPR spectroscopy
Edwards TE, Okonogi TM, Robinson BH, Sigurdsson ST
J Am Chem Soc. 2001, 123, 1527-8.
Chemical synthesis of cross-link lesions found in nitrous acid-treated DNA - A general method for preparation of N2-substituted 2�-deoxyguanosines
Harwood E, Hopkins PB, Sigurdsson ST
J. Org. Chem. 2000, 65, 2959-64.
Disulfide interstrand cross-linking of internal sugar residues in an RNA duplex
Alefelder S, Sigurdsson ST
Bioorg Med Chem. 2000, 8, 269-73.
Monoalkylation of DNA by reductively activated FR66979
Paz MM, Sigurdsson ST, Hopkins PB
Bioorg Med Chem. 2000, 8, 173-9.
Quantification of formaldehyde-mediated covalent adducts of adriamycin with DNA
Luce R, Sigurdsson ST, Hopkins PB
Biochemistry 1999, 121, 8682-90.
Long-range distance measurements to the phosphodiester backbone of solid nucleic acids using 31P-19F REDOR NMR
Merritt ME, Sigurdsson ST, Drobny GP
J Am Chem Soc. 1999, 121, 6070-1.
Chemical synthesis and preliminary structural characterization of a nitrous acid interstrand cross-linked duplex DNA
Harwood E, Sigurdsson ST, Edfeldt F, Reid B, Hopkins PB
J Am Chem Soc. 1999, 121, 5081-2.
Inter-domain cross-linking and molecular modelling of the hairpin ribozyme
Earnshaw DJ, Masquida B, Müller S, Sigurdsson ST, Eckstein F, Westhof E, Gait MJ
J Mol Biol. 1997, 274, 197-212.
In vitro selection of hammerhead ribozymes containing a bulged nucleotide in stem II
Thomson JB, Sigurdsson ST, Zeuch A, Eckstein F
Nucleic Acids Res. 1996, 24, 4401-6.
Probing the tertiary structure of the hairpin ribozyme by chemical cross-linking
Schmidt S, Earnshaw DJ, Sigurdsson ST
Coll Czech Chem Comm. 1996, 61, s276-79.
Isolation of oligoribonucleotides containing intramolecular cross-links
Sigurdsson ST, Eckstein F
Anal Biochem. 1996, 235, 241-42.
Site-specific labelling of sugar residues in oligoribonucleotides: Reactions of aliphatic isocyanates with 2'-amino groups
Sigurdsson ST, Eckstein F
Nucleic Acids Res. 1996, 24, 3129-34.
A mild and simple method for the preparation of isocyanates from aliphatic amines using trichloromethyl chloroformate. Synthesis of an isocyanate containing an activated disulfide
Sigurdsson ST, Seeger B, Kutzke U, Eckstein F
J Org Chem. 1996, 61, 3883-84.
An NMR study of [d(CGCGAATTCGCG)]2 containing an interstrand cross-link derived from a distamycin-pyrrole conjugate
Fagan PA, Spielman HP, Sigurdsson ST, Rink SM, Hopkins PB, Wemmer DE
Nucleic Acids Res. 1996, 24, 1566-73.
Probing RNA tertiary structure: Interhelical cross-linking of the hammerhead ribozyme
Sigurdsson ST, Tuschl T, Eckstein F
RNA 1995, 1, 575-83.
Synthesis and reactions with DNA of a family of DNA-DNA affinity cross-linking agents
Sigurdsson ST, Hopkins PB
Tetrahedron 1994, 50, 12065-84.
Affinity cross-linking of duplex DNA by a pyrrole-oligopeptide conjugate
Sigurdsson ST, Rink SM, Hopkins PB
J Am Chem Soc. 1993, 115, 12633-34.
DNA interstrand cross-linking reactions of pyrrole-derived, bifunctional electrophiles: Evidence for a common target site in DNA
Woo J, Sigurdsson ST, Hopkins PB
J Am Chem Soc. 1993, 115, 3407-15.
DNA interstrand cross-linking by reductively activated FR900482 and FR66979
Woo J, Sigurdsson ST, Hopkins PB
J Am Chem Soc. 1993, 115, 1199-1200.
Interstrand cross-linking of duplex DNA by nitrous acid: Covalent structure of the dG-to-dG cross-link at the sequence 5´-d(CG)
Kirchner JJ, Sigurdsson ST, Hopkins PB
J. Am. Chem. Soc. 1992, 114, 4021-27.
Sequence preferences of DNA interstrand cross-linking agents: dG-to-dG cross-linking at 5´-d(CG) by structurally simplified analogues of mitomycin C
Weidner MF, Sigurdsson ST, Hopkins PB
Biochemistry 1990, 29, 9225-33.
The preparation of triglycerides highly enriched with w-3 polyunsaturated fatty acids via lipase catalyzed interesterification
Haraldsson GG, Hoskuldsson PA, Sigurdsson ST, Thorsteinsson F, Gudbjarnarson S
Tetrahedron Lett. 1989, 30, 1671-74.